nuclear protein localization protein 4 homolog; protein NPL4 (NPLOC4, KIAA1499, NPL4)

Function

• component of NPLOC4-UFD1L-VCP complex
• ubiquitin fusion protein degradation (UFD) pathway
• heterodimer with UFD1L, the heterodimer binds ubiquitinated proteins & VCP
• binds ubiquitinated proteins via its RanBP2-type zinc finger

Structure

• belongs to the NPL4 family
• contains 1 RanBP2-type zinc finger

Compartment

• cytoplasm, endoplasmic reticulum, nucleus

Alternative splicing

named isoforms=2

More general terms

• zinc finger protein

Component of

• NPLOC4-UFD1L-VCP complex

Database

• OMIM: https://mirror.omim.org/entry/606590
• UniProt: http://www.uniprot.org/uniprot/Q8TAT6.html