huntingtin-interacting protein 1-related protein; HIP1-related protein; huntingtin-interacting protein 12; HIP-12 (HIP1R, HIP12, KIAA0655)

Function

• component of clathrin coated pits & vesicles
• interacts with actin
• binds 3-phosphoinositides (via ENTH domain)
• may act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis
• does not interact with huntingtin (putative)
• interacts with CLTB & huntingtin interacting protein 1 (HIP1
• homodimer; homodimerization promotes actin binding

Structure

• binds F-actin via the talin-like I/LWEQ domain
• belongs to the SLA2 family
• contains 1 ENTH (epsin N-terminal homology) domain
• contains 1 I/LWEQ domain

Compartment

• cytoplasm, perinuclear region, endomembrane system
• cytoplasmic vesicle, clathrin-coated vesicle membrane
• membrane-associated protein, mainly localized in the endocytic compartments & in the perinuclear region

Expression

• brain, heart, kidney, pancreas, & liver, but not in lung or placenta

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9026
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9026
• OMIM: https://mirror.omim.org/entry/605613
• UniProt: http://www.uniprot.org/uniprot/O75146.html