Tau-tubulin kinase 1; brain-derived tau kinase (TTBK1, BDTK, KIAA1855)

Function

• serine/threonine protein kinase
• phosphorylates TAU on Ser, Thr & Tyr
• induces aggregation of TAU

Cofactor: Mg+2 > Mn+2

Structure

• belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in neurons
  • expressed in the brain, particularly in cerebral cortex & hippocampus
  • weakly expressed in spinal cord
• weakly expressed in testis
• not expressed in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea

Notes

• uncertain whether Met-1 or Met-14 is the initiator

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84630
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84630
• UniProt: http://www.uniprot.org/uniprot/Q5TCY1.html