serine/threonine protein kinase pim-3 (PIM3)

Function

• proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival & protein translation
• may contribute to tumorigenesis through:
  • delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L)
  • regulation of cell cycle progression
  • protein synthesis
  • regulation of MYC transcriptional activity
• can negatively regulate insulin secretion by inhibiting activation of MAPK1/3 (ERK1/2), through SOCS6
• involved also in the control of energy metabolism & regulation of AMPK activity in modulating MYC & PPARGC1A protein levels
• ubiquitinated, leading to proteasomal degradation
• phosphorylated
• interaction with PPP2CA promotes dephosphorylation
• interacts with BAD
• interacts with PPP2CA
  • this interaction promotes dephosphorylation of PIM3, ubiquitination & proteasomal degradation
• interacts with SOCS6 (putative)

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm

Expression

• detected in heart, brain, lung, kidney, spleen, placenta, skeletal muscle, & peripheral blood leukocytes
• not found or barely expressed in normal adult endoderm- derived organs such as colon, thymus, liver, or small intestine; however, expression is augmented in premalignant & malignant lesions of these organs

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=415116
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:415116
• OMIM: https://mirror.omim.org/entry/610580
• UniProt: http://www.uniprot.org/uniprot/Q86V86.html