serine/threonine protein kinase 16; myristoylated & palmitoylated serine/threonine protein kinase; MPSK; protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; tyrosine-protein kinase STK16; hPSK (STK16, MPSK1, PKL12, TSF1)

Function

• membrane-associated protein kinase that phosphorylates on Ser & Thr
• in vitro substrates include DRG1, ENO1 & EIF4EBP1
• also autophosphorylates
• may be involved in secretory vesicle trafficking or
  • intracellular signaling
• may have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland
• may be involved in TGF-beta signaling
• able to autophosphorylate on Tyr
  • unclear whether it has tyrosine-protein kinase activity toward other proteins
• mainly autophosphorylated on Ser & Thr
• also autophosphorylated on Tyr-198
• uncertain whether palmitoylation is on Cys-6 &/or Cys-8
• monomer
• interacts with DRG1 (via its N-terminal)
  • interaction phosphorylates DRG1

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• cytoplasm, perinuclear region
• membrane lipid-anchor (putative)
• associates with Golgi & Golgi-derived vesicles (putative)

Expression

• ubiquitously expressed at very low levels

More general terms

• serine/threonine kinase
• myristoylated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8576
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8576
• OMIM: https://mirror.omim.org/entry/604719
• UniProt: http://www.uniprot.org/uniprot/O75716.html