tyrosine-protein phosphatase auxilin; DnaJ homolog subfamily C member 6 (DNAJC6, KIAA0473)

Function

• recruits HSPA8/HSC70 to clathrin-coated vesicles
• promotes uncoating of clathrin-coated vesicles
• interacts with HSPA8/HSC70, clathrin heavy chains
• interacts with CLTC
• interacts with AP2A2 (putative)

Structure

• contains 1 C2 tensin-type domain
• contains 1 J domain
• contains 1 phosphatase tensin-type domain

Alternative splicing

named isoforms=3

More general terms

• tyrosine phosphatase (protein tyrosine phosphatate, PTP)
• DNAJ homolog subfamily C

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9829
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9829
• OMIM: https://mirror.omim.org/entry/608375
• UniProt: http://www.uniprot.org/uniprot/O75061.html