clathrin heavy chain 1; CLH-17 (CLTC CLH17 CLTCL2 KIAA0034)
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Function
- clathrin is the major protein of the polyhedral coat of coated pits & vesicles
- two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network
- clathrin triskelions, composed of 3 heavy chains & 3 light chains, are the basic subunits of the clathrin coat
- in the presence of light chains, hub assembly is influenced by both the pH & the concentration of Ca+2
- interacts with HIP1
Structure
belongs to the clathrin heavy chain family
Compartment
- cytoplasmic vesicle membrane
- peripheral membrane protein; cytoplasmic side
- coated pit
- melanosome
- cytoplasmic face of coated pits & vesicles
- identified by mass spectrometry in melanosome fractions from stage 1 to stage 4
Alternative splicing
named isoforms=2
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q00610.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/CLTCID360.html
- ↑ Wikipedia; Note: clathrin entry http://en.wikipedia.org/wiki/clathrin
- ↑ Serafini T et al A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. Nature. 1991 Jan 17;349(6306):215-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1898984