ELAV-like protein 2; Hu-antigen B; HuB; ELAV-like neuronal protein 1; nervous system-specific RNA-binding protein Hel-N1 (ELAVL2, HUB)

Function

• RNA-binding protein
• seems to recognize a GAAA motif
• binds to 3'untranslated regions of mRNA (its own, c-fos, ID)
• interacts with IGF2BP1

Structure

• belongs to the RRM elav family
• contains 3 RRM domain (RNA recognition motif)s

Alternative splicing

named isoforms=2

Expression

brain; neural-specific

Pathology

• autoantigen of paraneoplastic syndromes (anti-Hu antibody)

More general terms

• RNA-binding protein
• antigen
• phosphoprotein

Additional terms

• anti-Hu antibody (type-1 ANNA)
• cerebellar degeneration related protein
• paraneoplastic cerebellar degeneration

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1993
• OMIM: https://mirror.omim.org/entry/601673
• UniProt: http://www.uniprot.org/uniprot/Q12926.html