Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23, ARHGAP23, KIAA1501)

Function

• GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state

Structure

• contains 1 PDZ domain (DHR domain)
• contains 1 PH domain
• contains 1 Rho-GAP domain

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, prostate, hippocampus, medulla

Pathology

• expressed in brain tumors, salivary gland tumor, head & neck cancer

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P227.html