n-chimaerin (neuronal chimaerin, alpha-chimerin, A-chimaerin, Rho GTPase-activating protein 2, CHN1, ARHGAP2, CHN)

Function

• GTPase-activating protein for p21-rac
• stimulates GTP hydrolysis by rac1 & rac2, but not by other rho subfamily proteins.
• phorbol ester receptor
• may play an important role in neuronal signal-transduction

Structure

• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 Rho-GAP domain
• contains 1 SH2 domain

Alternative splicing

named isoforms=2

Expression

• expressed in neurons in brain regions that are involved in learning & memory processes
• enriched in hippocampus
• increases in amount during brain development coincident with synaptogenesis

More general terms

• rho GTPase-activating protein (rho-GAP)
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/P15882.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1123
• OMIM: https://mirror.omim.org/entry/118423