Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1, ARHGAP4, P115)

Function

• inhibitory effect on stress fiber organization
• may down-regulate Rho-like GTPase in hematopoietic cells

Structure

• contains 1 FCH domain
• contains 1 Rho-GAP domain
• contains 1 SH3 domain

Compartment

• cytoplasm, ust below the plasma membrane

Expression

• predominantly in hematopoietic cells (spleen, thymus & leukocytes)
• low levels in placenta, lung & various fetal tissues

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:393
• OMIM: https://mirror.omim.org/entry/300023
• UniProt: http://www.uniprot.org/uniprot/P98171.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=393