rap1 GTPase-activating protein (rap1-GAP, RAP1GA1)
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Function
Structure
- contains 1 GoLoco domain
- contains 1 Rap-GAP domain
- total lack of similarity with ras-GAP
Compartment
- Golgi membrane, peripheral membrane
Expression
- expressed in brain, kidney & pancreas
- expression in cerebral cortex > spinal cord
- not detected in lymphoid tissues
- induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells
More general terms
References
- ↑ Bourne HR et al, The GTPase superfamily: a conserved switch for diverse cell functions Nature 348:125 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2122258
- ↑ Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20189751
- ↑ Swiss-Prot #P47736
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209