transcription factor COE2; early B-cell factor 2; EBF-2 (,EBF2 COE2)

Function

• transcription factor
• in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation
• acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway
• recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (putative)
• forms either a homodimer or a heterodimer with a related family member (putative)

Structure

• belongs to the COE family
• contains 1 IPT/TIG domain

Compartment

nucleus (putative)

More general terms

• COE family transcription factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64641
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64641
• OMIM: https://mirror.omim.org/entry/609934
• UniProt: http://www.uniprot.org/uniprot/Q9HAK2.html