forkhead box protein C2; forkhead-related protein 14; drosophila forkhead homolog-like 14 (FOXC2, FKHL14)

Function

• transcriptional activator
• role in formation of special mesenchymal tissues
• key regulator of adipocyte metabolism
• increases sensitivity of beta-adrenergic- cAMP protein kinase A signalling pathway through alteration of adipocyte PKA holoenzyme composition
• in mice, increased FOXC2 levels induced by high fat diet protects against obesity, diet-induced insulin resistance & hypertriglyceridemia

Structure

contains 1 fork-head DNA-binding domain

Compartment

nucleus

Pathology

• gene mutations found in lymphedema-distichiasis syndrome
• defects in FOXC2 are the cause of hereditary lymphedema 2
• defects in FOXC2 are a cause of lymphedema & ptosis
• defects in FOXC2 are a cause of yellow nail syndrome
• defects in FOXC2 are a cause of lymphedema-distichiasis

More general terms

• forkhead family transcription factor

Database

• OMIM: https://mirror.omim.org/entry/602402
• OMIM: https://mirror.omim.org/entry/153400
• UniProt: http://www.uniprot.org/uniprot/Q99958.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2303