ankyrin repeat, SAM & basic leucine zipper domain-containing protein 1; ankyrin-like protein 1; germ cell-specific ankyrin, SAM & basic leucine zipper domain-containing protein (ASZ1, ALP1, ANKL1, C7orf7, GASZ)
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Function
- role during spermatogenesis
- represses transposable elements & prevents their mobilization
- acts via piRNA metabolic process, which mediates repression of transposable elements during meiosis by forming complexes composed of piRNAs & Piwi proteins
- regulates methylation & subsequent repression of transposons
- association with pi-bodies suggests a participation in the primary piRNAs metabolic process
- required prior to the pachytene stage to facilitate production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons
- may act by mediating protein-protein interactions during germ cell maturation
- interacts with DDX4, PIWIL1, RANBP9 & TDRD1
Structure
- contains 6 ANK repeats
- contains 1 SAM (sterile alpha motif) domain
Compartment
- cytoplasm (putative)
- component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis
- specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (putative)
Expression
More general terms
- basic leucine zipper (bZIP) family protein
- ankyrin repeat domain protein (ANKRD)
- sterile alpha motif domain-containing protein (SAMD)