tudor domain-containing protein 1; cancer/testis antigen 41.1; CT41.1 (TDRD1)

Function

• role during spermatogenesis through repression of transposable elements & inhibition of their mobilization
• acts via the piRNA
  • mediates repression of transposable elements during meiosis by forming complexes composed of piRNAs & Piwi proteins
  • regulates methylation & subsequent repression of transposons
  • required for localization of Piwi proteins to the meiotic nuage
  • ensures entry of correct transcripts into the normal piRNA pool
• found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 & DDX4
• interacts with MAEL
• interacts with PIWIL1, PIWIL2 & PIWIL4 (when methylated on Arg)

Structure

• belongs to the TDRD1 family
• contains 1 MYND-type Zn+2 finger
• contains 4 Tudor domains

Compartment

• cytoplasm (putative)
• component of the meiotic nuage (P granule)
• also present in chromatoid body (putative)

Alternative splicing

named isoforms=4

Expression

• testis & ovary specific

Pathology

• expressed in several cancers

More general terms

• tudor domain-containing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56165
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56165
• OMIM: https://mirror.omim.org/entry/605796
• UniProt: http://www.uniprot.org/uniprot/Q9BXT4.html