ATP-dependent RNA helicase DDX4; DEAD box protein 4; vasa homolog (DDX4 VASA)

Function

• may play a role in germ cell development
• may play a role in sperm motility
• found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 & DDX4
• N-terminus interacts with RANBP9
• interacts with PIWIL2 & MAEL (putative)

Structure

• belongs to the DEAD box helicase family, DDX4/VASA subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• cytoplasm, perinuclear region

Alternative splicing

named isoforms=2

Expression

• expressed only in ovary & testis
• expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes

More general terms

• DEAD box ATP-dependent helicase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54514
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54514
• OMIM: https://mirror.omim.org/entry/605281
• UniProt: http://www.uniprot.org/uniprot/Q9NQI0.html