tudor domain-containing protein 6; antigen NY-CO-45; cancer/testis antigen 41.2; CT41.2 (TDRD6)

Function

• role in spermatogenesis, chromatoid body formation & for proper precursor & mature miRNA expression
• undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis-1 to meiosis-2 in primary spermatocytes (putative)
• found in a mRNP complex, composed of at least TDRD1, TDRD6, TDRD7 & DDX4
• found in a complex, composed of at least PIWIL1, PIWIL2 & TDRD6
• interacts with DDX4 & PIWIL1

Structure

contains 8 Tudor domains

Compartment

• cytoplasm (putative)
• present in chromatoid bodies of spermatids & in the intermitochondrial cementin in pachytene spermatocytes
• colocalizes with DDX4, PIWIL1, PIWIL2, TDRD1 & TDRD7 (putative)

More general terms

• tudor domain-containing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=221400
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:221400
• OMIM: https://mirror.omim.org/entry/611200
• UniProt: http://www.uniprot.org/uniprot/O60522.html