aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2; class E basic helix-loop-helix protein 1; bHLHe1 (ARNT2, BHLHE1, KIAA0307)

Introduction

see Ah receptor complex

Function

• Ah receptor binds to DNA as heterodimer with ARNT
• specifically recognizes the xenobiotic response element (XRE)
• efficient DNA binding requires dimerization with another bHLH protein
• heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein
• interacts with TACC3 (putative)

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 2 PAS (PER-ARNT-SIM) domains

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in brain, kidney, dorsal region of spinal cord & 1st branchial arch.

More general terms

• basic helix loop helix (bHLH) family transcription factor

Additional terms

• aromatic hydrocarbon
• aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2)
• aryl hydrocarbon [Ah] receptor complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9915
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9915
• OMIM: https://mirror.omim.org/entry/606036
• UniProt: http://www.uniprot.org/uniprot/Q9HBZ2.html