single-minded homolog 1; class E basic helix-loop-helix protein 14; bHLHe14 (SIM1, BHLHE14)

Function

• transcriptional factor
• may have pleiotropic effects during embryogenesis & in the adult
• efficient DNA binding requires dimerization with another bHLH protein
• heterodimer of SIM1 & ARNT

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 2 PAS (PER-ARNT-SIM) domains
• contains 1 single-minded C-terminal domain

Compartment

nucleus (putative)

More general terms

• single-minded homolog

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6492
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6492
• OMIM: https://mirror.omim.org/entry/603128
• UniProt: http://www.uniprot.org/uniprot/P81133.html