Krueppel-like factor 7; ubiquitous krueppel-like factor (KLF7, UKLF)

Function

• transcriptional activator
• binds in vitro to the CACCC motif of the beta-globin promoter & to the SP1 recognition sequence

Structure

• the acidic N-terminal part may favor interaction with the basic domain of transcription factors
• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Expression

• ubiquitous
• highly expressed in brain & spinal cord in adults highly expressed in kidney & brain in the embryo

More general terms

• Krueppel-like factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8609
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8609
• OMIM: https://mirror.omim.org/entry/604865
• UniProt: http://www.uniprot.org/uniprot/O75840.html