Krueppel-like factor 3; basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2 (KLF3, BKLF)

Function

• binds to the CACCC box of erythroid cell-expressed genes
• may play a role in hematopoiesis (putative)
• sumoylated by SUMO1
• sumoylation is enhanced by PIAS1, PIAS2alpha & PIAS2beta, & PIAS4, but not by Pc2
• enhances transcriptional repression, but has no effect on DNA binding
• sumoylation on Lys-198 is the major site (putative)
• monomer (putative)

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Alternative splicing

• named isoforms=2
• at least one isoform may be due to intron retention

More general terms

• Krueppel-like factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51274
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51274
• OMIM: https://mirror.omim.org/entry/609392
• UniProt: http://www.uniprot.org/uniprot/P57682.html