myelin expression factor 2 (MyEF-2, MST156, MYEF2 KIAA1341)

Function

• transcriptional repressor of the myelin basic protein gene
• binds to the proximal MB1 element 5'-TTGTCC-3' of the myelin basic protein gene promoter
• binding to MB1 & function are inhibited by PURA

Structure

• contains 3 RRM domains (RNA recognition motif domains)

Compartment

nucleus

Alternative splicing

named isoforms=4

More general terms

• transcriptional silencer (transcriptional repressor)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P2K5.html