suppression of tumorigenicity protein 18 (zinc finger protein 387, ST18, KIAA0535, ZNF387)

Function

• transcriptional repressor that binds to DNA sequences containing a bipartite element direct repeat of 5'-AAAGTTT-3' separated by 2-9 nucleotides.
• represses basal transcription activity from target promoters
• inhibits colony formation in cultured breast cancer cells

Compartment

nucleus

Expression

• expressed at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary, prostate > mammary epithelial cells, breast cancer cells

More general terms

• transcriptional silencer (transcriptional repressor)
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/O60284.html