Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37 (CDC37, CDC37A)

Function

• co-chaperone that binds to numerous kinases & promotes their interaction with the Hsp90 complex, resulting in stabilization & promotion of their activity
• constitutively sumoylated by UBE2I
• forms a complex with Hsp90
• interacts with AR, CDK4, CDK6, EIF2AK1 & RB1

Structure

belongs to the CDC37 family

Compartment

cytoplasm

More general terms

• chaperonin; chaperone
• phosphoprotein

Additional terms

• heat shock protein [hsp]-90

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11140
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11140
• OMIM: https://mirror.omim.org/entry/605065
• UniProt: http://www.uniprot.org/uniprot/Q16543.html