Ca+2-binding protein 8; CaBP8; calneuron I; calneuron-1 (CALN1, CABP8)

Function

• negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB & inhibiting its activity (putative)
• may play a role in the physiology of neurons
• may play a role in learning & memory
• interacts with PI4KB; this binding competes with FREQ/NCS1 binding (Ca+2-dependent)

Structure

• the C-terminal transmembrane domain (TMD) is necessary & sufficient for membrane targeting
• contains 2 EF-hand domains

Compartment

• Golgi, trans-Golgi network
• cell membrane
• single-pass type IV membrane protein (probable)
• cytoplasm, perinuclear region

Expression

brain specific

More general terms

• Ca+2 binding protein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83698
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83698
• OMIM: https://mirror.omim.org/entry/607176
• UniProt: http://www.uniprot.org/uniprot/Q9BXU9.html