17 beta-hydroxysteroid dehydrogenase-1; estradiol 17 beta-dehydrogenase 1; 20 alpha-hydroxysteroid dehydrogenase (HSD17B1)

Function

• converts androstenedione to testosterone & estrone to estradiol
• may be two different enzymes under different control, one localized to testes
• only reversible enzyme system involved in steroid biosynthesis
• favors the reduction of estrogens & androgens
• 20-alpha-HSD activity
• estrogens biosynthesis
• favors NAD

estradiol-17-beta + NAD+/NADP+ <--> estrone + NADH/NADPH

Structure

• homodimer
• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

cytoplasm

More general terms

• 17 beta-hydroxysteroid dehydrogenase
• 20-hydroxysteroid dehydrogenase or cortisone reductase
• oligomerizing protein

Database

• UniProt: http://www.uniprot.org/uniprot/P14061.html
• OMIM: https://mirror.omim.org/entry/109684