aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; high-affinity hepatic bile acid-binding protein; HBAB; chlordecone reductase homolog HAKRC; dihydrodiol dehydrogenase 1/2; DD1/DD2 (AKR1C1, DDH, DDH1)

Function

• converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP)
• in the liver & intestine, may have a role in the transport of bile
• may have a role in monitoring the intrahepatic bile acid concentration
• may play a role in myelin formation

17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD+/NADP+
                <-->
17-alpha-hydroxyprogesterone + NADH/NADPH

trans-1,2-dihydrobenzene-1,2-diol + NADP+ <--> catechol + NADPH

Structure

• monomer
• belongs to the aldo/keto reductase family

Compartment

cytoplasm

Expression

• expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland & keratinocytes
• highest levels found in liver, mammary gland & brain

More general terms

• trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
• aldo-keto reductase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1645
• OMIM: https://mirror.omim.org/entry/600449
• UniProt: http://www.uniprot.org/uniprot/Q04828.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1645