K+ channel subfamily T member 1 (KCa4.1, KCNT1, KIAA1422)

Function

• generates outwardly rectifying currents
• may co-assemble with other Slo-type channel subunits
• activated by high intracellular Na+ or Cl- levels
• suppressed by elevation of intracellular Ca+2
• activated upon stimulation of G-protein coupled receptors, such as CHRM1 & GRIA1
• phosphorylated by protein kinase C
• phosphorylation of the C- terminal domain increases channel activity (putative)
• interacts with CRBN via its cytoplasmic C-terminus

Structure

• belongs to the K+ channel family, Ca+2-activated (TC 1.A.1.3) subfamily, KCa4.1/KCNT1 sub-subfamily
• contains 1 RCK N-terminal domain

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• expressed in liver, brain, spinal cord > skeletal muscle

More general terms

• K+ channel subfamily T
• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/608167
• UniProt: http://www.uniprot.org/uniprot/Q5JUK3.html