protein cereblon (CRBN)

Function

• involved in memory & learning (putative)
• although CRBN contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain the ATP-binding & catalytic domains

Alternative splicing

named isoforms=2

Expression

highly expressed in brain

Pathology

• defects in CRBN associated with nonsyndromic mental retardation, autosomal recessive 2a (MRT2A)

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/607417
• UniProt: http://www.uniprot.org/uniprot/Q96SW2.html