K+ channel subfamily K member 9; acid-sensitive K+ channel protein TASK-3; TWIK-related acid-sensitive K+ channel 3; Two pore K+ channel KT3.2 (KCNK9 TASK3)

Function

• pH-dependent, voltage-insensitive, background K+ channel

Structure

• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane (potential)

Expression

• mainly found in the cerebellum
• also found in adrenal gland, kidney & lung

Pathology

• overexpressed in a high proportion of breast cancers
• may confer resistance to growth factor deprivation & hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors
• defects in KCNK9 may be the cause of Birk Barel syndrome

Notes

• inhibited by phorbol 12-myristate 13-acetate (PMA)
• TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0

More general terms

• K+ channel subfamily K
• glycoprotein
• transmembrane 6 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NPC2.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51305
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51305
• OMIM: https://mirror.omim.org/entry/605874