monocarboxylate transporter 2; MCT 2; solute carrier family 16 member 7 (SLC16A7, MCT2)

Function

• proton-linked monocarboxylate transporter
• catalyzes rapid transport across the plasma membrane of many monocarboxylates including:
  • lactate
  • pyruvate
  • branched-chain oxo acids derived from leucine, valine & isoleucine
  • ketone bodies
    • acetoacetate
    • beta-hydroxybutyrate
    • acetate
• high affinity pyruvate transporter
• interacts with GRID2IP (putative)

Structure

• belongs to the major facilitator superfamily monocarboxylate porter (TC 2.A.1.13) family

Compartment

cell membrane

Expression

• high expression in testis
• moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain & leukocytes
• restricted expression in normal tissues
• widely expressed in cancer cells

More general terms

• monocarboxylate transporter
• solute carrier family 16 (SLC16, SLC16A)

Database

• OMIM: https://mirror.omim.org/entry/603654
• UniProt: http://www.uniprot.org/uniprot/O60669.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9194