acetoacetate; beta-ketobutyrate; 3-ketobutyrate

Biochemistry

• acetoacetate produced in the liver during periods of fasting or exercise
• transfer of CoA from succinyl CoA to form acetoacetyl CoA & subsequently 2 acetyl CoA molecules by thiolase
• acetyl CoA enters the citric acid cycle

Physiology

• heart muscle & renal cortex prefer acetoacetate as an energy source over glucose
• the brain uses acetoacetate when glucose levels are low due to fasting

Laboratory

• acetoacetate in blood
• acetoacetate in CSF
• acetoacetate in serum/plasma
• acetoacetate in urine

More general terms

• carboxylate
• ketone

More specific terms

• acetoacetyl coenzyme A

Additional terms

• acetoacetate in serum/plasma
• ketone bodies in body fluid

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=96