monocarboxylate transporter 1; MCT 1; solute carrier family 16 member 1 (SLC16A1, MCT1)

Function

• proton-linked monocarboxylate transporter
• catalyzes rapid transport across the plasma membrane of many monocarboxylates including:
  • lactate
  • pyruvate
  • branched-chain oxo acids derived from leucine, valine & isoleucine
  • ketone bodies
    • acetoacetate
    • beta-hydroxybutyrate
    • acetate

Structure

• belongs to the major facilitator superfamily monocarboxylate porter (TC 2.A.1.13) family

Compartment

cell membrane

Expression

widely expressed in normal & in cancer cells

Pathology

• defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport

More general terms

• monocarboxylate transporter
• solute carrier family 16 (SLC16, SLC16A)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6566
• OMIM: https://mirror.omim.org/entry/156575
• OMIM: https://mirror.omim.org/entry/245340
• OMIM: https://mirror.omim.org/entry/600682
• UniProt: http://www.uniprot.org/uniprot/P53985.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6566