C-C motif chemokine 16; chemokine CC-4; HCC-4; chemokine LEC; IL-10-inducible chemokine; LCC-1; liver-expressed chemokine; lymphocyte & monocyte chemoattractant; LMC; monotactin-1; MTN-1; NCC-4; small-inducible cytokine A16 (CCL16, ILINCK, NCC4, SCYA16)

Function

• chemotactic for lymphocytes & monocytes
• not chemotactic for neutrophils
• potent myelosuppressive activity
  • suppresses proliferation of myeloid progenitor cells
• recombinant SCYA16
  • chemotactic activity for monocytes & THP-1 monocytes,
  • not chemotactic for resting lymphocytes or neutrophils
• induces a Ca+2 flux in THP-1 cells that are desensitized by prior expression to RANTES

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• mainly expressed in liver
• also found in spleen & thymus
• highly expressed in LPS- & IFN-gamma-activated monocytes
• weakly expressed in some lymphocytes, including NK cells, gamma-delta T-cells, & some T-cell clones
• induced by IL-10

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6360
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6360
• OMIM: https://mirror.omim.org/entry/601394
• UniProt: http://www.uniprot.org/uniprot/O15467.html