C-C motif chemokine 22; CC chemokine STCP-1; MDC(1-69); macrophage-derived chemokine; small-inducible cytokine A22; stimulated T-cell chemotactic protein 1 (CCL22, MDC, SCYA22, A-152E51)

Function

• may play a role in the trafficking of activated/effector T-cells to inflammatory sites
• chemotactic for monocytes, dendritic cells & NK cells
• mild chemoattractant for primary activated T-cells & a potent chemoattractant for chronically activated T-cells
• not chemotactic for neutrophils, eosinophils, or resting T-cells
• binds to CCR4
• processed forms MDC(3-69), MDC(5-69) & MDC(7-69) may not be active
• the N-terminal processed forms MDC(3-69), MDC(5-69) & MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• highly expressed in macrophage & in monocyte-derived dendritic cells, & thymus
• also found in lymph node, appendix, activated monocytes, resting & activated macrophages
• lower expression in lung & spleen
• very weak expression in small intestine
• in lymph node, expressed in a mature subset of Langerhans' cells (CD1a+ & CD83+)
• expressed in Langerhans' cell histiocytosis
• not expressed in dermatopathic lymphadenopathy
• expressed in atopic dermatitis, allergic contact dermatitis, & psoriasis, in both the epidermis & dermis

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6367
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6367
• OMIM: https://mirror.omim.org/entry/602957
• UniProt: http://www.uniprot.org/uniprot/O00626.html