C-C motif chemokine 19; beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; macrophage inflammatory protein 3 beta; MIP-3-beta; small-inducible cytokine A19 (CCL19, ELC, MIP3B, SCYA19)

Function

• may play a role not only in inflammatory & immunological responses but also in normal lymphocyte recirculation & homing
• may play a role in trafficking of T-cells in thymus, & T-cell & B-cell migration to secondary lymphoid organs
• specifically binds to chemokine receptor CCR7
• recombinant CCL19
  • potent chemotactic activity for T-cells & B-cells
  • not chemotactic for granulocytes or monocytes

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• expressed lymph nodes, thymus & appendix > colon & trachea > spleen, small intestine, lung, kidney & stomach

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6363
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6363
• OMIM: https://mirror.omim.org/entry/602227
• UniProt: http://www.uniprot.org/uniprot/Q99731.html