C-C motif chemokine 25; chemokine TECK; small-inducible cytokine A25; thymus-expressed chemokine (CCL25, SCYA25, TECK)

Function

• role in T-cell development (probable)
• recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, & dendritic cells
  • inactive on peripheral blood lymphocytes & neutrophils
• binds to CCR9
• isoform 2 is an antagonist of isoform 1

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• specifically expressed by thymic dendritic cells
• expressed at high levels in thymus & small intestine

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6370
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6370
• OMIM: https://mirror.omim.org/entry/602565
• UniProt: http://www.uniprot.org/uniprot/O15444.html