C-C chemokine receptor type 9; C-C CKR-9; CC-CKR-9; CCR-9; GPR-9-6; G-protein coupled receptor 28; CDw199 (CCR9, CMKBR9, GPR28)

Function

• receptor for chemokine SCYA25/TECK
• subsequently transduces a signal by increasing the intracellular Ca+2

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in the thymus & low in lymph nodes & spleen

Pathology

• alternative coreceptor with CD4 for HIV-1 infection

Notes

• EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2

More general terms

• CC chemokine receptor
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1080
• OMIM: https://mirror.omim.org/entry/604738
• UniProt: http://www.uniprot.org/uniprot/P51686.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10803