leukotriene C4 synthase; LTC4 synthase; leukotriene-C(4) synthase (LTC4S)

Function

• catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4
• interacts with ALOX5AP & ALOX5

Leukotriene C4 = leukotriene A4 + glutathione

Structure

• homotrimer
• belongs to the MAPEG family

Compartment

• nuclear outer membrane
• endoplasmic reticulum membrane
• multi-pass membrane protein

Expression

• detected in lung, platelets & the myelogenous leukemia cell line KG-1 (at protein level)
• LTC4S activity is present in eosinophils, basophils, mast cells, some phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells & platelets

Pathology

• defects in LTC4S are the cause of leukotriene C4 synthase deficiency

More general terms

• lyase
• transmembrane 3 protein
• nuclear protein

Additional terms

• leukotriene C4

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4056
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4056
• OMIM: https://mirror.omim.org/entry/246530
• UniProt: http://www.uniprot.org/uniprot/Q16873.html