Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein (ALOX5AP, FLAP)
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Function
- required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase)
- anchors ALOX5 to the membrane
- binds arachidonic acid, & could play an essential role in the transfer of arachidonic acid to ALOX5
- after release by phospholipase, arachidonic acid is translocated to bind the integral perinuclear membrane protein, FLAP
- FLAP appears to activate Ca+2-dependent 5-lipoxygenase activty
- binds to MK-886, a compound that blocks the biosynthesis of leukotrienes
- Inhibited by DG-013[4]
- interacts with LTC4S & ALOX5
Structure
- homotrimer
- the C-terminal part after residue 140 is mostly unstructured
- belongs to the MAPEG family
Compartment
- nuclear membrane
- endoplasmic reticulum membrane
Pathology
- genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke
- haplotypes hapA & hapB are associated with susceptibility to myocardial infarction
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P20292.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/alox5ap/
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1861
- ↑ 4.0 4.1 Hakonarson H, Thorvaldsson S, Helgadottir A, Gudbjartsson D, Zink F, Andresdottir M, Manolescu A, Arnar DO, Andersen K, Sigurdsson A, Thorgeirsson G, Jonsson A, Agnarsson U, Bjornsdottir H, Gottskalksson G, Einarsson A, Gudmundsdottir H, Adalsteinsdottir AE, Gudmundsson K, Kristjansson K, Hardarson T, Kristinsson A, Topol EJ, Gulcher J, Kong A, Gurney M, Thorgeirsson G, Stefansson K. Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial. JAMA. 2005 May 11;293(18):2245-56. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15886380
Database
- UniProt: http://www.uniprot.org/uniprot/P20292.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=241
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:241
- OMIM: https://mirror.omim.org/entry/601367
- OMIM: https://mirror.omim.org/entry/603700
- OMIM: https://mirror.omim.org/entry/608557