mevalonate kinase (MVK)

Function

• cholesterol biosynthesis
  • may be a regulatory site in cholesterol biosynthetic pathway
• isoprenoid biosynthesis
  • isopentenyl-PP biosynthesis via mevalonate pathway
  • isopentenyl-PP from R-mevalonate: step 1/3
• farnesyl-pyrophosphates & geranyl-pyrophosphate are competitive inhibitors

ATP + (R)-mevalonate <--> ADP + (R)-5-phosphomevalonate

Structure

• homodimer
• belongs to the GHMP kinase family, mevalonate kinase subfamily

Compartment

cytoplasm, peroxisome

Pathology

• defects associated with
  • mevalonicaciduria
  • hyper IgD syndrome

More general terms

• kinase or ATP-phosphotransferase

Additional terms

• cholesterol biosynthesis

Database

• UniProt: http://www.uniprot.org/uniprot/Q03426.html
• OMIM: https://mirror.omim.org/entry/251170
• OMIM: https://mirror.omim.org/entry/260920
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4598