epidermal growth factor (EGF) receptor kinase substrate 8-like protein 1; EPS8-like protein 1; epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-related protein 1 (EPS8L1 DRC3 EPS8R1 PP10566)

Function

• stimulates guanine exchange activity of SOS1
• membrane ruffling
• remodelling of the actin cytoskeleton
• interacts with ABI1, F-actin
• component of complex that contains SOS1, ABI1, EPS8L2

Structure

• belongs to the EPS8 family
• contains 1 SH3 domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

expressed in placenta

More general terms

• epidermal growth factor receptor kinase substrate 8-like protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54869
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54869
• UniProt: http://www.uniprot.org/uniprot/Q8TE68.html