fermitin family homolog 2; kindlin-2; mitogen-inducible gene 2 protein; MIG-2; pleckstrin homology domain-containing family C member 1; PH domain-containing family C member 1 (FERMT2, KIND2, MIG2, PLEKHC1)

Function

• role in the connection between ECM adhesion sites & the actin cytoskeleton & also in the orchestration of actin assembly & cell shape modulation
• recruits migfilin (FBLP1) protein to cell-extracellular matrix focal adhesion sites
• interacts with FBLP1

Structure

• the FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain
• belongs to the kindlin family
• contains 1 FERM domain
• contains 1 PH domain

Compartment

• cytoplasm, cell cortex, cytoskeleton
• cell junction, focal adhesion
• within actin stress fibers at cell-ECM focal adhesion sites

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• found in numerous tumor tissues
• induced by serum in lung fetal fibroblast cultured cells

Notes

may be due to an exon inclusion & an intron retention

More general terms

• kindlin
• pleckstrin homology domain containing family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10979
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10979
• OMIM: https://mirror.omim.org/entry/607746
• UniProt: http://www.uniprot.org/uniprot/Q96AC1.html