PDZ & LIM domain protein 5 (Enigma homolog, Enigma-like PDZ & LIM domains protein, PDLIM5, ENH)

Function

• role in the heart development by scaffolding PKC to Z-disk region
• interacts with various PKC isoforms via LIM domains
• interacts with actin & alpha-actinin via PDZ domain

Structure

• contains 3 LIM zinc-binding domains
• contains 1 PDZ domain (DHR domain)

Expression

heart & skeletal muscle specific

Pathology

• role in genetic susceptibility to schizophrenia
• PDLIM5 is commonly increased in the brain of patients with bipolar disorder, schizophrenia, & major depression

More general terms

• PDZ & LIM domain protein

Database

• OMIM: https://mirror.omim.org/entry/605904
• UniProt: http://www.uniprot.org/uniprot/Q96HC4.html