gamma-2-syntrophin; G2SYN; syntrophin-5; SYN5 (SNTG2)

Function

• adapter protein
• binds to & probably organizes the subcellular localization of a variety of proteins
• may link various receptors to the actin cytoskeleton & the dystrophin glycoprotein complex (putative)
• interacts with the dystrophin protein DMD & related proteins DTNA & DTNB

Structure

• association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (putative)
• belongs to the syntrophin family
• contains 1 PDZ domain (DHR domain)
• contains 1 PH domain

Compartment

• cell membrane, sarcolemma
• peripheral membrane protein; cytoplasmic side
• cytoplasm, cytoskeleton
• in skeletal muscle, localizes at the cytoplasmic side of the sarcolemmal membrane
• in CNS, expressed in the perikaryon & proximal portion of neuronal processes

Expression

• widely expressed
• strong expression in brain & testis
• strong expression in the hippocampus, neuron-rich dendate granule cells, & pyramidal cell layers
• highly expressed in neurons of the cerebral cortex
• also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, & basal ganglia

More general terms

• syntrophin (dystrophin-associated protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54221
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54221
• OMIM: https://mirror.omim.org/entry/608715
• UniProt: http://www.uniprot.org/uniprot/Q9NY99.html