formin-like protein 1 (leukocyte formin, CLL-associated antigen KW-13, FMNL1, C17orf1, C17orf1B, FMNL)

Function

• control of cell motility & survival of macrophages (putative)
• interacts with RAC1, PFN1 & PFN2

Structure

• belongs to the formin homology family
• contains 1 DAD domain (diaphanous autoregulatory domain)
  • contains 1 FH2 domain (formin homology 2 domain)
  • contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• formin homology family protein

Database

• OMIM: https://mirror.omim.org/entry/604656
• UniProt: http://www.uniprot.org/uniprot/O95466.html