centaurin-delta-1; Arf-GAP with Rho-GAP domain, ANK repeat & PH domain-containing protein 2; Cnt-d1; protein PARX (ARAP2, CENTD1, KIAA0580)

Function

• PI(3,4,5)P3-dependent GTPase
• modulates actin cytoskeleton remodeling by regulating ARF & RHO family members
• activated by PI(3,4,5)P3 binding

Structure

• contains 1 Arf-GAP domain
• contains 5 PH domains
• contains 1 Ras-associating domain
• contains 1 Rho-GAP domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

cytoplasm

Expression

• expressed in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes

More general terms

• centaurin delta
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116984
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:116984
• OMIM: https://mirror.omim.org/entry/606645
• UniProt: http://www.uniprot.org/uniprot/Q8WZ64.html