RNA-binding protein 15; RNA-binding motif protein 15; one-twenty two protein 1 (RBM15, OTT OTT1)

Function

• may be implicated in HOX gene regulation
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with Epstein-Barr virus BSFL2/BMLF1

Structure

• belongs to the RRM spen family
• contains 3 RRM domains (RNA recognition motif)
• contains 1 SPOC domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Pathology

• chromosomal translocation t(1;22)(p13;q13) involving RBM15 with MKL1 may be a cause of acute megakaryoblastic leukemia
• although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene & is the candidate oncogene

More general terms

• nuclear protein
• RNA-binding motif protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64783
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64783
• OMIM: https://mirror.omim.org/entry/606077
• UniProt: http://www.uniprot.org/uniprot/Q96T37.html