chromosomal translocation t(1;22)(p13;q13) (acute megakaryoblastic leukemia)

Pathology

• chromosomal translocation t(1;22)(p13;q13) involving MKL1 with RBM15 may be a cause of acute megakaryoblastic leukemia
• both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7)
• the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene & is the candidate oncoprotein

More general terms

• chromosomal translocation

Additional terms

• AML-M7; acute megakaryoblastic leukemia